DBSCR - Transcription factor

Database of transcriptional regulation in Streptomyces

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GenBank ID	no data
Factor type	ND
Pfam	None
Consensus seq.	ND
Comment	FdmR1 was shown to be a SARP-type activator regulating FDM production. RT-PCR studies revealed that up to 26 of the 28 genes within the fdm cluster were controlled by FdmR1. Titers of FDMs were signi?cantly improved, to 1.36g/liter, by overexpressing fdmR1 in S. griseus ATCC 49344.

Regulated Gene	Sigma	Regulation	Location	Binding seq.(cis-element)	Experimental evidence	Organism
fdmC	None	Positive	`-50:+10`	`CGTGCCGTGGCCTCTTCGAGCCTGCCTCGAGGCGGCTGGACGATGCTCACGCCCGGCCGG`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344
fdmD	None	Positive	`-50:+10`	`GACGTCGAGCTGGCCTGGACCGGCCCTCAAGCCGCCCGGGCCAGCATCACGTCCCGACAG`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344
fdmM	None	Positive	`-50:+10`	`CCCGTCGAGCGCCGCTCCACAGCGAATCGAGCAGGCGGCGCCAGGGTGGCGGCACCACCC`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344
fdmM1	None	Positive	`-50:+10`	`ATCATCGAGCCGTCTTCGAGGCCGTTTCGACCACCGGGGCCGAAGGTCGGGGCCGGAGGC`	Chen Y, et al. (2008): DB, OV, HM	S. griseus ATCC 49344
fdmT1	None	Positive	`-50:+10`	`CGCGTCCACCGGCCTTCAAGTGAGTTTCGAGCCCTCCCCCTGAGGCTGACCGCGTCAGAA`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344
fdmV	None	Positive	`-50:+10`	`ACCATCCAGCGCCCCTCCACGCGGTTTCGAGCGGTGCGGGAAACGCTGGACGCCGACGGC`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344
fdmR1	None	Positive	`-50:+10`	`CTTGTCGAGTACCGCTCAAGCAGAAGTCAAGTAATCGCCCGCACGCTCACGAAGCGCATC`		S. griseus ATCC 49344
fdmW	None	Positive	`-50:+10`	`CGGCTCCGGCGCTGTTCGAGCCGGCGTCGAGCCGCCGGTGCGAGCCTGCCCGTATGCAAC`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344
fdmR2	None	Positive	`-50:+10`	`GCCTTCCAGCCGTTCACCAGCGTCCCTCGAGTCGGCGCGGGCACCGTGGGCGGCACGGGG`	Chen Y, et al. (2008): DB, OV, HM, RT-PCR	S. griseus ATCC 49344