DBSCR - Regulated genes

   Database of transcriptional regulation in Streptomyces coelicolor

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Regulated gene: fabD

Operons: fabDHPF

Genes Gene ID Synonyms Direction Genome position Function
fabD SCO2387 SC4A7.15, fabD + 2559340..2560290 malonyl CoA:acyl carrier protein malonyltransferase
fabH SCO2388 SC4A7.16, fabH + 2560307..2561338 3-oxoacyl-[acyl-carrier-protein] synthase III
acpP SCO2389 SC4A7.17, acpP + 2561443..2561691 acyl carrier protein
fabF SCO2390 SC4A7.18, fabF + 2561801..2563090 3-oxoacyl-[acyl-carrier-protein] synthase II

Operon evidence: RT-PCR, S1, Disruption
Reference: Revill WP, et al. (2001)
Comments: In this study we provide further biochemical evidence for the role of a small cluster of presumed fab genes (which includes fabH) in Streptomyces coelicolor and a transcriptional analysis of the fab cluster, and we have attempted to disrupt fabH to determine if it is essential for the viability of the cells.


Promoters

Binding
factor
Promoter
name
Regulation Location Absolute position Binding seq.(cis-element) Experimental evidence
FasR - Positive -87:-67(from translation start site) 2559253..2559273 TTTTGTGCAGGGTCCACAAAA Xu D, et al. (2010): OV, HM, GS, qRT-PCR

Comments:
FasR A novel transcription factor, FasR (SCO2386), controls expression of fabDHPF operon and lies immediately upstream of fabD, in a cluster of genes that is highly conserved within actinomycetes. Expression of fab genes was downregulated in the fasR mutant, indicating a role for this transcription factor as an activator. FasR binds specifically to a DNA sequence containing fabDHPF promoter region, both in vivo and in vitro.


Terminator

No Data

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Copyright: BASE, RIKEN
Contact: Yuko Makita