DBSCR - Regulated genes

   Database of transcriptional regulation in Streptomyces coelicolor
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Regulated gene: pikC

Operon: No data
Genes Gene ID Synonyms Function
pikC

Promoters

Binding
factor		 Promoter
name		 Regulation Location Binding seq.(cis-element) Experimental evidence Organism
PikD - Positive ND ND Jung WS, et al. (2008): RT-PCR, OV
Wilson DJ, et al. (2001): DB, RG (Direct/Indirect is not clear)
 S. venezuelae

Comments:
PikD A genetic analysis of PikD using the xylE reporter system showed that the PikD regulator activates the pikAI promoter, whereas it directly or indirectly represses desI promoter, and does not participate in pikC regulation in wild-type S. venezuelae. Gene expression analysis by reverse transcriptase PCR and bioconversion experiments of 10-deoxymethynolide, narbonolide, and TL into the corresponding desosaminyl macrolides indicated that PikD is a positive regulator of the des and pikC genes, as well as the Pik PKS genes.

Terminator

No Data

DBSCR:

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Contact: Yuko Makita