Transcription factor: PikD
| GenBank ID |
3800841 |
| Factor type |
ND |
| Pfam |
PF00196 (Bacterial regulatory proteins, luxR family
)
|
| Consensus seq. |
ND |
| Comment |
PikD is a pathway-specific positive regulator of the entire pikromycin (Pik) biosynthetic pathway. It enhances heterologously produced tlactone (TL) and desosaminyl tylactone (DesTL). Park SR, et al (2008) suggested that PikD enhance epothilone production 2-fold, although these increased yields of epothilones in S. venezuelae were still significantly low compared ro those of other heterologous hosts, S. coelicolor and M. xanthus. |
| pikC |
None |
Positive |
ND |
ND |
Jung WS, et al. (2008): RT-PCR, OV
Wilson DJ, et al. (2001): DB, RG (Direct/Indirect is not clear)
|
S. venezuelae |
| desVIII |
None |
Positive |
ND |
ND |
Jung WS, et al. (2008): RT-PCR, OV
Wilson DJ, et al. (2001): DB, RG (Direct/Indirect is not clear)
|
S. venezuelae |
| pikRII |
None |
Positive |
ND |
ND |
Wilson DJ, et al. (2001): DB, RG (Direct/Indirect is not clear)
|
S. venezuelae |
| pikAI |
None |
Positive |
ND |
ND |
Jung WS, et al. (2008): RT-PCR, OV
Wilson DJ, et al. (2001): DB, RG (Direct/Indirect is not clear)
|
S. venezuelae |
| desI |
None |
Positive |
ND |
ND |
Jung WS, et al. (2008): RT-PCR, OV
Wilson DJ, et al. (2001): DB, RG (Direct/Indirect is not clear)
|
S. venezuelae |
|