Transcription factor: AfsR-sv
| GenBank ID |
148728352 |
| Factor type |
ND |
| Pfam |
PF03704 (Bacterial transcriptional activator domain
)
|
| Consensus seq. |
ND |
| Comment |
RT-PCR analysis was carried out to assess the expression levels of two representative genes: the ketosynthase (KS) gene and pikD. RT-PCR assays demonstrated that afsR-sv functions as a positive regulator and is involved in the regulation of pikromycin biosynthesis in S. venezuelae. Overexpression of afsR-sv in S. venezuelae seemed to activate the transcription of ketosynthase and a pathway-specific regulator, both resulting in the overproduction of pikromycin. |
|