DBSCR - Transcription factor

   Database of transcriptional regulation in Streptomyces coelicolor

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Transcription factor: SigH

Gene ID SCO5243 (link to ScoCyc)
Factor type Sigma70
Pfam PF04542 (Sigma-70 region 2 ) PF04539 (Sigma-70 region 3 ) PF04545 (Sigma-70, region 4 )
Consensus seq. ND
Comment Stress response sigma factor with a dual role in salt stress-response and morphological differentiation; sigH has two isoforms, sig52 and sig37 (Sevcikova J,et al. 2002). Kim YJ, et al. 2008(PMID: 19087294) also suggested sigH is also strongly upregulated by the pH shock.
Link to Weight matrix & Motif alignment

Regulated Gene Absolute position Location Binding seq.(cis-element) Experimental evidence
ushX 5705695..5705754 -50:+10 GACCTGTGCCCGGGACGGTTCGACCGTCTGACGTCTGGGTACGTCAACCCGGCGCGCGCT Kormanec J, et al. (2000): S1
Sevcikova B, et al. (2002): DB
Sevcikova B, et al. (2001): S1
dagA 3832749..3832808 -50:+10 ACTTACCTCCTGGAGCCTAGCTCCTCCTGCGCCGTGGAATGATCGTGCCACGTGGGCGTT Kang JG, et al. (1997): GS, RO
Buttner MJ, et al. (1988): RO
Fujii T, et al. (1996): RO
Buttner MJ, et al. (1987): S1
Servin-Gonzalez L, et al. (1994): S1
Viollier PH, et al. (2003): Western blots (Immunodetection of SigH isoforms)
actIII 5529583..5529642 -50:+10 GGTAAGGAGGGGTTGCGCGTGTTCGTCTGCGCGCGCGGCGAAGAAGGACTGCGGACGACG Kang JG, et al. (1997): GS, RO
gltB 2176734..2176793 -50:+10 GTAGCCGTTACTCGCTGGTTTCGAGCGCGTAATCTCCGGGCATGAGCCGTAAGCGCTGCG Kormanec J, et al. (2002): S1, DB
ssgB 1650275..1650334 -50:+10 GCAAAACACTCAGAGGGGTTTACAACGGCACCGTAGGTGGCATGTCGATTTCGCCGACGT Kormanec J, et al. (2002): S1, DB
sigJ 1346643..1346702 -50:+10 GAGGTGCGTATTCCGGTTTGCCGCTCCAGGGCCTCGGGTAGAAAATCCACATGGCCGAAC Mazurakova V, et al. (2006): S1, DB, RO
ctc ND ND ND Viollier PH, et al. (2003): RO




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Contact: Yuko Makita