DBSCR - Transcription factor

   Database of transcriptional regulation in Streptomyces coelicolor
Home
 Transcription factors
 Regulated genes
 Revised TLS
 Search
 Contacts

List of Transcription Factors
The classification of factors below is based on the existence of the Pfam motifs (Sanger Center, UK). We manually selected Pfam domains that are functionally related to transcription factors. Since these motifs do not always correspond to DNA-binding domains, a factor can belong to multiple families.
Link to S. griseus and other Streptomyces

Helix turn helix family
Fe_dep_repress Iron dependent repressor, N-terminal DNA binding domain
FUR Ferric uptake regulator family
GerE Bacterial regulatory proteins, luxR family
GntR Bacterial regulatory proteins, gntR family
HTH_1 Bacterial regulatory helix-turn-helix protein, lysR family
HTH_3 Helix-turn-helix
HTH_IclR IclR helix-turn-helix domain
HTH_WhiA Sporulation Regulator WhiA C terminal domain
MarR MarR family
TetR_N Bacterial regulatory proteins, tetR family
Trans_reg_C Transcriptional regulatory protein, C terminal
HTH_AraC Bacterial regulatory helix-turn-helix proteins, AraC family
MerR MerR family regulatory protein
GAF domain-like family
IclR Bacterial transcriptional regulator
TetR protein, C-terminal domain-like family
TetR_C Tetracyclin repressor, C-terminal all-alpha domain
Transcriptional repressor beta-barrel domain family
FeoA FeoA domain
Other family
AsnC_trans_reg AsnC family
FCD FCD domain
Fe_dep_repr_C Iron dependent repressor, metal binding and dimerisation domain
LysR_substrate LysR substrate binding domain
Response_reg Response regulator receiver domain
TPR_4 Tetratricopeptide repeat
Whib Transcription factor WhiB
BTAD Bacterial transcriptional activator domain
Sigma factors
Sigma70_r1_2 Sigma-70 factor, region 1.2
Sigma70_r2 Sigma-70 region 2
Sigma70_r3 Sigma-70 region 3
Sigma70_r4 Sigma-70, region 4
Sigma70_r4_2 Sigma-70, region 4
Not assigned
ND Not assigned to Pfam domains


Helix turn helix family

 Domain: Fe_dep_repress
Gene Other
family		 Functional
description		 Num. of
regulated genes
DmdR1 Fe_dep_repr_C, FeoAiron repressor1
DesR2 Fe_dep_repr_C, FeoAiron dependent repressor0
Go to top


 Domain: FUR
Gene Other
family		 Functional
description		 Num. of
regulated genes
CatR Trans_reg_C, BTADhydrogen peroxide sensitive repressor2
FurA
Fe regulatory protein1
Nur
putative iron uptake regulatory protein5
Zur
putative metal uptake regulation protein8
Go to top


 Domain: GerE
Gene Other
family		 Functional
description		 Num. of
regulated genes
AbsA2 Response_regtwo component system response regulator3
AcsR
putative response regulator1
LipR TPR_4putative transcriptional activator1
RamR Response_regputative two-component system response regulator2
RedZ
response regulator2
WhiI
two-component regulator9
WhiK Response_regputative two-component regulator0
Go to top


 Domain: GntR
Gene Other
family		 Functional
description		 Num. of
regulated genes
Agl3R FCDputative gntR-family transcriptional regulator2
WhiH FCDsporulation transcription factor, WhiH7
DevA
putative GntR-family transcriptional regulator1
DasR
putative gntR-family transcriptional regulator8
Go to top


 Domain: HTH_1
Gene Other
family		 Functional
description		 Num. of
regulated genes
OxyR LysR_substratehydrogen peroxide sensing regulator2
AbaB LysR_substrateputative lysR-family transcriptional regulator0
Go to top


 Domain: HTH_3
Gene Other
family		 Functional
description		 Num. of
regulated genes
BldD
putative DNA-binding protein13
MurA2
putative UDP-N-acetylglucosamine transferase0
Go to top


 Domain: HTH_IclR
Gene Other
family		 Functional
description		 Num. of
regulated genes
GylR IclRglycerol operon regulatory protein2
HpdR IclRputative transcriptional regulator4
SsgR IclRputative transcriptional regulator1
Go to top


 Domain: HTH_WhiA
Gene Other
family		 Functional
description		 Num. of
regulated genes
WhiA
hypothetical protein5
Go to top


 Domain: MarR
Gene Other
family		 Functional
description		 Num. of
regulated genes
OhrR
putative regulatory protein2
Ptr
putative transcriptional regulator2
SCO6704
putative transcriptional regulator1
Go to top


 Domain: TetR_N
Gene Other
family		 Functional
description		 Num. of
regulated genes
Pip TetR_Cputative tetR family transcriptional regulatory protein1
PqrA
putative tetR-family transcriptional regulator1
ScbR
gamma-butyrolactone binding protein4
XdhR
putative tetR-family transcriptional regulator2
RrdA
putative tetR-family transcriptional regulatory protein1
ActII TetR_Cputative transcriptional regulatory protein0
CprA
transcriptional regulator0
CprB
A-factor receptor homolog0
Go to top


 Domain: Trans_reg_C
Gene Other
family		 Functional
description		 Num. of
regulated genes
ActII-ORF4
actinorhodin cluster activator protein4
AfsR TPR_4regulatory protein5
CatR FUR, BTADhydrogen peroxide sensitive repressor2
CseB Response_regtwo-component system response regulator2
GlnRII
putative regulatory protein3
GlnR
transcriptional regulatory protein14
PhoP Response_regputative response regulator26
VanR Response_regputative two-component system response regulator4
RapA1 Response_regprobable two-component system response regulator7
KdpE Response_regputative turgor pressure regulator0
Go to top


 Domain: HTH_AraC
Gene Other
family		 Functional
description		 Num. of
regulated genes
AdpA
araC-family transcriptional regulator4
NrdS
putative araC-family transcriptional regulator0
Go to top


 Domain: MerR
Gene Other
family		 Functional
description		 Num. of
regulated genes
BldC
putative DNA-binding protein4
LitR
putative DNA-binding regulator0
Go to top

GAF domain-like family

 Domain: IclR
Gene Other
family		 Functional
description		 Num. of
regulated genes
GylR HTH_IclRglycerol operon regulatory protein2
HpdR HTH_IclRputative transcriptional regulator4
SsgR HTH_IclRputative transcriptional regulator1
Go to top

TetR protein, C-terminal domain-like family

 Domain: TetR_C
Gene Other
family		 Functional
description		 Num. of
regulated genes
Pip TetR_Nputative tetR family transcriptional regulatory protein1
ActII TetR_Nputative transcriptional regulatory protein0
Go to top

Transcriptional repressor beta-barrel domain family

 Domain: FeoA
Gene Other
family		 Functional
description		 Num. of
regulated genes
DmdR1 Fe_dep_repress, Fe_dep_repr_Ciron repressor1
DesR2 Fe_dep_repress, Fe_dep_repr_Ciron dependent repressor0
Go to top

Other family

 Domain: AsnC_trans_reg
Gene Other
family		 Functional
description		 Num. of
regulated genes
HpdA
putative asnC-family transcriptional regulator3
LrpA
putative AsnC-family transcriptional regulator0
Go to top


 Domain: FCD
Gene Other
family		 Functional
description		 Num. of
regulated genes
Agl3R GntRputative gntR-family transcriptional regulator2
WhiH GntRsporulation transcription factor, WhiH7
Go to top


 Domain: Fe_dep_repr_C
Gene Other
family		 Functional
description		 Num. of
regulated genes
DmdR1 Fe_dep_repress, FeoAiron repressor1
DesR2 Fe_dep_repress, FeoAiron dependent repressor0
Go to top


 Domain: LysR_substrate
Gene Other
family		 Functional
description		 Num. of
regulated genes
OxyR HTH_1hydrogen peroxide sensing regulator2
AbaB HTH_1putative lysR-family transcriptional regulator0
Go to top


 Domain: Response_reg
Gene Other
family		 Functional
description		 Num. of
regulated genes
AbsA2 GerEtwo component system response regulator3
CseB Trans_reg_Ctwo-component system response regulator2
PhoP Trans_reg_Cputative response regulator26
RamR GerEputative two-component system response regulator2
VanR Trans_reg_Cputative two-component system response regulator4
RapA1 Trans_reg_Cprobable two-component system response regulator7
OsaB
two-component regulator0
KdpE Trans_reg_Cputative turgor pressure regulator0
WhiK GerEputative two-component regulator0
Go to top


 Domain: TPR_4
Gene Other
family		 Functional
description		 Num. of
regulated genes
AfsR Trans_reg_Cregulatory protein5
LipR GerEputative transcriptional activator1
Go to top


 Domain: Whib
Gene Other
family		 Functional
description		 Num. of
regulated genes
WhiB
sporulation regulatory protein4
WblA
putative regulatory protein5
WblE
hypothetical protein0
WblI
hypothetical protein0
Go to top


 Domain: BTAD
Gene Other
family		 Functional
description		 Num. of
regulated genes
CatR FUR, Trans_reg_Chydrogen peroxide sensitive repressor2
Go to top

Sigma factors

 Domain: Sigma70_r1_2
Gene Other
family		 Functional
description		 Num. of
regulated genes
HrdB Sigma70_r3, Sigma70_r2, Sigma70_r4major vegetative sigma factor21
HrdD Sigma70_r3, Sigma70_r2, Sigma70_r4RNA polymerase principal sigma factor3
Go to top


 Domain: Sigma70_r2
Gene Other
family		 Functional
description		 Num. of
regulated genes
BldN Sigma70_r4_2putative RNA polymerase sigma factor1
HrdB Sigma70_r3, Sigma70_r4, Sigma70_r1_2major vegetative sigma factor21
HrdD Sigma70_r3, Sigma70_r4, Sigma70_r1_2RNA polymerase principal sigma factor3
LitS Sigma70_r4putative sigma factor3
Sig31 Sigma70_r4_2RNA polymerase sigma factor1
SigB Sigma70_r3, Sigma70_r4RNA polymerase sigma factor sig815
SigE Sigma70_r4_2ECF sigma factor4
SigF Sigma70_r3, Sigma70_r4RNA polymerase sigma factor1
SigG Sigma70_r3, Sigma70_r4putative RNA polymerase secondary sigma factor2
SigH Sigma70_r3, Sigma70_r4RNA polymerase sigma factor6
SigN Sigma70_r3, Sigma70_r4putative RNA polymerase sigma factor2
SigR Sigma70_r4_2RNA polymerase sigma factor34
WhiG Sigma70_r3, Sigma70_r4RNA polymerase sigma factor WhiG8
SigT Sigma70_r4_2putative RNA polymerase sigma factor0
SigK Sigma70_r3, Sigma70_r4putative RNA polymerase sigma factor0
SigI Sigma70_r3, Sigma70_r4putative RNA polymerase sigma factor0
SigJ Sigma70_r4_2, Sigma70_r3, Sigma70_r4RNA polymerase ECF sigma factor0
Go to top


 Domain: Sigma70_r3
Gene Other
family		 Functional
description		 Num. of
regulated genes
HrdB Sigma70_r2, Sigma70_r4, Sigma70_r1_2major vegetative sigma factor21
HrdD Sigma70_r2, Sigma70_r4, Sigma70_r1_2RNA polymerase principal sigma factor3
SigB Sigma70_r2, Sigma70_r4RNA polymerase sigma factor sig815
SigF Sigma70_r2, Sigma70_r4RNA polymerase sigma factor1
SigG Sigma70_r2, Sigma70_r4putative RNA polymerase secondary sigma factor2
SigH Sigma70_r2, Sigma70_r4RNA polymerase sigma factor6
SigN Sigma70_r2, Sigma70_r4putative RNA polymerase sigma factor2
WhiG Sigma70_r2, Sigma70_r4RNA polymerase sigma factor WhiG8
SigK Sigma70_r2, Sigma70_r4putative RNA polymerase sigma factor0
SigI Sigma70_r2, Sigma70_r4putative RNA polymerase sigma factor0
SigJ Sigma70_r4_2, Sigma70_r2, Sigma70_r4RNA polymerase ECF sigma factor0
Go to top


 Domain: Sigma70_r4
Gene Other
family		 Functional
description		 Num. of
regulated genes
HrdB Sigma70_r3, Sigma70_r2, Sigma70_r1_2major vegetative sigma factor21
HrdD Sigma70_r3, Sigma70_r2, Sigma70_r1_2RNA polymerase principal sigma factor3
LitS Sigma70_r2putative sigma factor3
SigB Sigma70_r3, Sigma70_r2RNA polymerase sigma factor sig815
SigF Sigma70_r3, Sigma70_r2RNA polymerase sigma factor1
SigG Sigma70_r3, Sigma70_r2putative RNA polymerase secondary sigma factor2
SigH Sigma70_r3, Sigma70_r2RNA polymerase sigma factor6
SigN Sigma70_r3, Sigma70_r2putative RNA polymerase sigma factor2
WhiG Sigma70_r3, Sigma70_r2RNA polymerase sigma factor WhiG8
SigK Sigma70_r3, Sigma70_r2putative RNA polymerase sigma factor0
SigI Sigma70_r3, Sigma70_r2putative RNA polymerase sigma factor0
SigJ Sigma70_r4_2, Sigma70_r3, Sigma70_r2RNA polymerase ECF sigma factor0
Go to top


 Domain: Sigma70_r4_2
Gene Other
family		 Functional
description		 Num. of
regulated genes
BldN Sigma70_r2putative RNA polymerase sigma factor1
Sig31 Sigma70_r2RNA polymerase sigma factor1
SigE Sigma70_r2ECF sigma factor4
SigR Sigma70_r2RNA polymerase sigma factor34
SigT Sigma70_r2putative RNA polymerase sigma factor0
SigJ Sigma70_r3, Sigma70_r2, Sigma70_r4RNA polymerase ECF sigma factor0
Go to top

Not assigned

 Domain: ND
Gene Other
family		 Functional
description		 Num. of
regulated genes
AmfC
aerial mycelium formation2
AtrA
secreted protein2
BldB
putative regulator, BldB1
BldG
putative anti-sigma factor antagonist3
HspR
putative heat shock protein3
MalR
maltose operon transcriptional repressor1
RbpA
hypothetical protein SC6D7.18c.1
Rex
conserved hypothetical protein2
SigU
putative RNA polymerase sigma factor8
NrdR
conserved hypothetical protein SC4H2.252
Unknown_sigma
unknown sigma factor90
RsrA
anti-sigma factor1
NsdA
putative regulator1
AbsB
hypothetical protein1
SsgA
putative regulator8
AbeR
putative regulatory protein1
AbsC
putative transcriptional regulator4
BkdR
putative transcriptional regulator1
SoxR
putative merR-family transcriptional regulator5
NdgR
putative regulator2
SCO3201
putative tetR-family transcriptional regulator2
FasR
conserved hypothetical protein SC4A7.141
SCO1712
putative TetR-family transcriptional regulator5
SCO5405
putative transcriptional regulator2
SCO6008
probable transcriptional repressor protein1
SCO1480
conserved hypothetical protein2
Go to top